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Tag: Major Depressive Disorder

Resting-state connectivity predictors of response to psychotherapy in major depressive disorder.

Abstract Despite the heterogeneous symptom presentation and complex etiology of major depressive disorder (MDD), functional neuroimaging studies have shown with remarkable consistency that dysfunction in mesocorticolimbic brain systems are central to the disorder. Relatively less research has focused on the identification of biological markers of response to antidepressant treatment that would serve to improve the personalized delivery of empirically supported antidepressant interventions. In the present study, we investigated whether resting-state…
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Cognitive Therapy plus Medication is More Effective than Medication Alone in the Treatment of Depression

OBJECTIVE: To determine the effects of combining cognitive therapy (CT) with ADM vs ADM alone on remission and recovery in major depressive disorder (MDD). METHOD: A total of 452 adult outpatients with chronic or recurrent MDD participated in a trial conducted in research clinics at 3 university medical centers in the United States. The patients were randomly assigned to ADM treatment alone or CT combined with ADM treatment. Treatment was…
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CT is as Effective as Fluoxetine in Preventing Depressive Relapses

A recent study published in JAMA Psychiatry showed Cognitive Therapy (CT) to be as effective as medication (Fluoxetine) in reducing the risk of major depressive disorder (MDD) relapse. Participants in the current study included 523 adults with a diagnosis of MDD and a score of 14 or higher on the Hamilton Rating Scale for Depression. They were recruited from clinical referrals and advertisements during 2000 to 2008. Researchers employed a…
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Long-Term Study on Family Group Cognitive-Behavioral Preventative Intervention Shows Promising Results in Children Whose Parents Have Major Depressive Disorder

A recent study published in the Journal of Consulting and Clinical Psychology found that a family group cognitive-behavioral (FGCB) preventative intervention for children (9-15 years old) whose parents have suffered from Major Depressive Disorder (MDD) significantly lowered the rates of MDD onset in children during a 2-year intervention period. The rates of MDD in children in the FGCB preventative intervention were reduced by half compared to a written information group…
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